Simon and Kamina live in an underground city monitored by the village chief. When Simon stumbles upon an artifact and beastmen invade from the surface, Simon and Kamina rebel against them.

In the aftermath of the Fourth Impact, stranded without their Evangelions, Shinji, Asuka and Rei find refuge in one of the rare pockets of humanity that still exist on the ruined planet Earth. ...

Seven years after the defeat of the spiral king, Simon and the Dai-Gurren brigade must set out to the vastness of space to defeat a new threat and save the universe.